Molecular pharmaceutics
The Core Protein of the Syndecan-4 Ectodomain on Small Extracellular Vesicles Promotes Fusion with Endosomes.
Ryuta Yamanaka, Hiroki Nagumo, Rumina Ema, Mana Iwamoto, Toshihiko Sugiki, Yuki Takechi-Haraya, Norihito Shibata, Yasuomi Kiyota, Mayuko Takeda-Shitaka, Kumiko Sakai-Kato
Published: 202610.1021/acs.molpharmaceut.5c01494
Abstract
Small extracellular vesicles (sEVs) can efficiently transfer payloads, such as nucleic acids, into the cytosol of cells. Endocytosis is a major pathway for the intracellular trafficking of sEVs, and some sEVs can fuse with late endosomes to release c…
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