Molecular pharmaceuticsBiological ProductsDiffusionViscosityDrug CompoundingDehydration
A Dehydration-Diffusion Competition Framework Predicts Interfacial Film Risk in High-Concentration Biologics Fill-Finish.
Yu-Jiun Lin, Ruomeng Qiu, Qi Gao, Yu Tian, Iriny Ekladious, Mark McCoy, Katelyn Smith, Hanmi Xi, Adam Procopio, Wei Xu
Published: 202510.1021/acs.molpharmaceut.5c01406
Abstract
High-concentration protein formulations are increasingly demanded for the development of subcutaneous injections owing to its clinical and commercial advantages. However, their high protein concentrations can lead to dried residues, causing failures…
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