Molecular pharmaceuticsFreeze DryingAntibodiesMonoclonalFreezingDrug Compounding
Contradictory Effects of Different Freezing Rates on Visible Bubbles and Reconstitution Time during the Reconstitution of Freeze-Dried High-Concentration Monoclonal Antibody Formulations.
Han Gao, Yi-Mei Sun, Jun Ouyang, Zhao-Lin Ding, Chang-Yun Xiong, You-Ru Wang, Rui Xing, Wei-Jie Fang
Published: 202510.1021/acs.molpharmaceut.5c01347
Abstract
The freezing rate is a critical factor governing ice nucleation and growth during freeze-drying, which directly determines the microvoid architecture of the freeze-dried cake and its reconstitution properties. This study systematically evaluates the…
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