Decoding the Structure-Function Correlation of Adeno-Associated Virus 2 Capsid Mutants Recognition by A20 Antibody: A Predictive Modeling Using Coarse-Grained Simulations.

Adeno-associated virus serotype 2 (AAV2) is widely used as a gene therapy vector due to its favorable safety profile and broader transduction capabilities. However, pre-existing immunity poses a significant barrier to its therapeutic applications. In…

Preview only. Read the full abstract at the source