Molecular pharmaceuticsHumansNucleotidyltransferasesImmunotherapyNeoplasmsMembrane Proteins
Targeting the cGAS-STING Pathway for Cancer Immunotherapy: From Small-Molecule Agonists to Advanced Nanomaterials.
Zhibin Guo, Tingting Liu, Qichao Gao, Caiyu Wang, Qing Wang, Ruili Du, Yufei Liu, Hanping Li, Yan Huang, Yi Liu, Yujiao Liu
Published: 202510.1021/acs.molpharmaceut.5c01263
Abstract
The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) signaling pathway has emerged as a pivotal mediator of antitumor immunity, bridging innate and adaptive immune responses through its ability to sense cytoplasmic DNA and orchestr…
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