Journal of proteome researchAnimalsRatsProteomicsInsulin-Secreting CellsSignal Transduction
Impact of PPP1R1A Knockdown on the Proteomic Landscape of INS-1 Cells: A Focus on Significant Modulated Pathways.
Jalal Taneera, Alexander D Giddey, Nelson C Soares, Anila Khalique, Abdul Khader Mohammed, Mohamed Omer Mahgoub, Eglal Mahgoub
Published: 202610.1021/acs.jproteome.5c00889
Abstract
PPP1R1A (protein phosphatase 1 regulatory inhibitor subunit 1A) is a cAMP/PKA-responsive inhibitor of protein phosphatase 1 (PP1) with a pivotal role in pancreatic β-cell physiology. To investigate its functional impact, Ppp1r1a was silenced in INS-1…
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