Journal of proteome researchProteomicsHumansHeLa CellsTandem Mass SpectrometryPeptides
Use of Synthetic Standard Peptides in Standardized Digests to Evaluate Both Sample and Instrument Suitability in Proteomics.
Leonard B Collins, Taufika Islam Williams, Alexandria L Sohn, Jaclyn G Kalmar, Michael S Bereman, David C Muddiman
Published: 202510.1021/acs.jproteome.5c00415
Abstract
Whole proteome digests are routinely used to diagnose chromatograph and mass spectrometer outputs to ensure suitability for the analysis of complex matrices, but their usage inherently fails to prove system reliability under varying "load" conditions…
Preview only. Read the full abstract at the source