The journal of physical chemistry lettersHydrophobic and Hydrophilic InteractionsGasesMolecular Dynamics SimulationMembrane ProteinsProtein Structure
Hydrophobic Shielding Preserves Transmembrane Secondary Structure in the Gas Phase.
Yongqi Zhang, Lanbi Zhang, Juhong Wu, Han Zhang, Lin Liu, Ping Gao, Jinyu Li
Published: 202510.1021/acs.jpclett.5c03514
Abstract
Electrospray ionization mass spectrometry (ESI-MS) can transfer membrane proteins into the gas phase under native-like conditions, preserving noncovalent assemblies and overall folds. Nevertheless, how much of their secondary structure survives after…
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