The journal of physical chemistry. BAdenylyl CyclasesMolecular Dynamics SimulationCalmodulinColforsinCatalytic Domain
Synergistic Interplay of Stimulatory Cofactors in the Activation of Adenylyl Cyclase Isoform 1.
Tongtong Li, Shreya Krishnan, Talon Hicks, Jianing Li
Published: 202510.1021/acs.jpcb.5c04367
Abstract
Adenylyl Cyclase isoform 1 (AC1), responsible for synthesizing the signaling molecule cyclic adenosine monophosphate (cAMP), is key in synaptic plasticity, long-term chronic pain syndromes, osteosarcoma-associated pain, and drug abuse. The protein ca…
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