The Journal of organic chemistry
Simplified Protocol Conditions for the Gold-Catalyzed Hydrofluorination of Terminal Aliphatic Alkynes.
Raphaël Pronovost, Claudia Gagnon, Nikolaos V Tzouras, Steven P Nolan, Jean-François Paquin
Published: 202610.1021/acs.joc.5c02743
Abstract
We report, herein, a simplified protocol for the gold-catalyzed hydrofluorination of the terminal alkynes. The system employs [Au(IPr)Cl], the simplest NHC-gold complex, in a diluted HFIP/toluene solvent mixture, uses the readily available Et3N·3HF r…
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