The Journal of organic chemistry
Primary Amine-Catalyzed Enantioselective Fluorination of α-Branched Aldehydes with Low Catalyst Loadings.
Katsuki Endo, Sohta Sakahara, Daiki Tomon, Riko Genka, Kanami Sugiyama, Masahiro Higashi, Satoru Arimitsu
Published: 202510.1021/acs.joc.5c02738
Abstract
β,β-diaryl-β-silyloxy diamines enable catalytic enantioselective fluorination of α-branched aldehydes with a broad substrate scope, even at low catalyst loadings (>90% ee, 1-3 mol %). Furthermore, as a synthetic application, the enantioselective synt…
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