The Journal of organic chemistry
Second-Generation Synthesis and Analytical Application of TBBA for Chiral Analysis of Amino Acids and Oligopeptides by 1H and 19F NMR Spectroscopy.
David Profous, Naděžda Cankařová, Jakob Enengl, Sarin Soji, Uwe Rinner, Petr Jurečka, Petr Cankař
Published: 202610.1021/acs.joc.5c02693
Abstract
A concise and efficient second-generation synthesis of 2-(2-(trifluoromethyl)-1H-benzo[d]imidazol-1-yl)benzoic acid (TBBA) has been developed. The synthesis affording enantiomerically pure TBBA atropisomers was significantly streamlined through optic…
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