The Journal of organic chemistry
Radical Cascade Cyclization of Unsaturated Aldehyde Hydrazones for the Synthesis of Trifluoromethylated Tetrahydropyridazine and Dihydropyrazole Skeletons.
Lian Ma, Ying Zhao, Guirong You
Published: 202610.1021/acs.joc.5c02470
Abstract
Herein, we report a cascade cyclization reaction mediated by trifluoromethyl radicals using N-allyl and homoallyl aldehyde hydrazones and CF3SO2Na as the starting materials. This approach enables the efficient synthesis of 30 trifluoromethylated tetr…
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