Biomimetic Cationic Tail-to-Head Cyclizations of Linear Sesquiterpenols Enabled by Stabilizing the Cationic Intermediates with 1,1,1,3,3,3-Hexafluoroisopropanol (HFIP).

In nature, cationic tail-to-head cyclizations of the diphosphates of a few linear sesquiterpenols generate a vast array of structurally diverse polycyclic sesquiterpenes. However, in normal organic solvents, cationic cyclizations of linear sesquiterp…

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