The Journal of organic chemistry
Highly Enantioselective Hydroxylation of 1-Indanone-Derived β-Ketoesters Catalyzed by a Newly Designed C1-Symmetric Salan-Zr Complex.
Cunfei Ma, Kun Tang, Yufeng Wu, Yakun Wang, Qilei Liu, Jingnan Zhao, Jianing Li, Liyuan Duan, Xiangmin Tian, Qingwei Meng
Published: 202610.1021/acs.joc.5c02269
Abstract
An efficient L17-Zr(IV)-catalyzed protocol for the enantioselective synthesis of chiral α-hydroxy-β-ketoesters derived from 1-indanone was presented. At loadings as low as 0.5-1.0 mol %, C1-Symmetric chiral Salan ligand promotes the hydroxylation of…
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