The Journal of organic chemistry
Mild LiOMe-Catalyzed Trifluoromethylation of Carbonyl Compounds.
Santhosh Reddy Naini, Venumadhav Janganati, Arun D R Shada, Srinivasarao Tenneti, Srijita Bhowmik, Jonathan Bietsch, Praveen Gajula, Venkatarathnam Nasipireddy, Leila Terrab, Jinya Yin, Nageswara Rao Kalikinidi, Chanaka Amarasekarage, Sameera Siyabalapitiya Arachchige, Shanika M P Gamage, Nuwan Kondasinghe
Published: 202610.1021/acs.joc.5c02246
Abstract
We report a mild lithium methoxide (LiOMe)-catalyzed protocol for the trifluoromethylation of aldehydes, acyclic and cyclic ketones, and α,β-unsaturated carbonyl compounds. This method avoids the use of fluorinated or strong bases that promote enoliz…
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