The Journal of organic chemistryCopperNaproxenIbuprofenCatalysisAnti-Inflammatory Agents
Copper-Catalyzed Site-Specific α-Azidation of Ibuprofen and Naproxen Analogs.
Wenqun Zhang, Ruisheng Zhao, Dan Liu, Tegshi Muschin, Agula Bao, Chaolumen Bai, Yong-Sheng Bao
Published: 202610.1021/acs.joc.5c02234
Abstract
Ibuprofen and Naproxen analogs serve as nonsteroidal anti-inflammatory drugs and are the main drugs used to reduce pain, fever, and inflammation. Herein, we report a copper-catalyzed method for the first site-specific α-C(sp3)-H azidation reaction of…
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