Cationic Cyclization of 1,6-Enynes for the Synthesis of Methylene Glutarimides.

Based on glutarimide's excellent phamaceutical bioactivities, herein, we developed a Brønsted acid-mediated cationic cyclization reaction of 1,6-enynes with electron-deficient alkyne as terminator. And the substrates can be easily transformed into di…

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