The Journal of organic chemistry
An Alternative Synthetic Route to Rilzabrutinib via an E-Configured Cyanoacrylic Acid Intermediate.
Daibao Wei, Jinbo Guo, Fuqiang Zhu, Emmanuel Mintah Bonku, Changliang Sun, Peng Yang, Hongjian Qin, Jingshan Shen
Published: 202510.1021/acs.joc.5c02058
Abstract
In this manuscript, an alternative route of synthesis for making rilzabrutinib via amide formation was described. The two segments for the amide formation are pyrazolopyrimidine-piperidine 20 and E-cyanoacrylic acid 21. The yield of 20 from Mitsunobu…
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