The Journal of organic chemistryStereoisomerismEscherichia coliMolecular StructureBiocatalysisSubstrate Specificity
A ThDP-Dependent Enzyme with a Broad Nucleophilic Substrate Spectrum: Stereoselective Carboligation Reactions Catalyzed by Escherichia coli SucA.
Weichao Dai, Anissa Afonso, Virgil Hélaine, Thierry Gefflaut, Jean-Louis Petit, Véronique de Berardinis, Michael Müller, Christine Guérard-Hélaine, Marielle Lemaire
Published: 202610.1021/acs.joc.5c02017
Abstract
Most bioactive molecules possess complex structures with multiple functionalities and chiral centers. Consequently, their synthesis often involves numerous steps, leading to low overall yields. An eco-friendly solution is to use the EcSucA enzyme, wh…
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