The Journal of organic chemistry
Ir-f-Amphbinol-Catalyzed Asymmetric Hydrogenation of N-Protected α-Amino Ketones Followed by Deprotection for Preparation of β-Primary Amino Alcohols.
Weilong Wu, Wanyang Chen, Wenzhi Mo, Ning Qiu, Yueru Hao, Xiaolei Ge, Feng Zhang, Bingqing Liu, Dongsheng Deng, Yan Zhou, Baoming Ji
Published: 202510.1021/acs.joc.5c01927
Abstract
We have successfully developed a highly efficient Ir-f-Amphbinol-catalyzed asymmetric hydrogenation for various α-amino ketones with different substituents on the -NH2. A series of α-amino ketones containing easily introduced and removed groups (Boc-…
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