The Journal of organic chemistry
Synthesis of Isoquinoline/Quinoline/Carboline-Substituted Methylamine Derivatives by an Interrupted Ugi Three-Component Reaction.
Lei Wang, Yangkai Wang, Xianxiu Xu, Guodong Wang, Shaoguang Sun, Mengying Jia
Published: 202510.1021/acs.joc.5c01763
Abstract
A hexafluoroisopropanol (HFIP)-promoted Ugi three-component reaction of electron rich aryl, alkenyl or heteroaryl group-tethered isocyanides, aldehydes and amines was developed for the rapid and general synthesis of a wide range of isoquino-line/quin…
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