The Journal of organic chemistry
HFIP/BF3·Et2O Synergistic Catalysis Enables Intramolecular Alkyne Cyclization to Coumarins.
Yu Zhao, Yu Cheng, Quanye Liu, Mengyi Li, Wei Li, Di Wu
Published: 202510.1021/acs.joc.5c01199
Abstract
We have successfully developed a novel synergistic catalytic system employing hexafluoroisopropanol (HFIP)/BF3·Et2O for intramolecular alkyne cyclization, which enables efficient construction of coumarin frameworks. This metal-free protocol features…
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