Journal of medicinal chemistry
Valine-Alanine-Based Peptidomimetic Linker for Antibody-Drug Conjugates.
Yalong Li, Yifan Wang, Yingxin Lu, Jiajun Xie, Jie Hu, Fengyuan Pan, Qiqin Wang, Wei Lu, Juan Zhang, Shulei Zhu
Published: 202610.1021/acs.jmedchem.5c03548
Abstract
Antibody-drug conjugates (ADCs) hold immense potential for novel linker modifications. However, the instability of current ADC peptide linkers in long-term in vivo circulation can lead to premature toxin release and safety concerns. This study explor…
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