Journal of medicinal chemistryAnimalsAlzheimer DiseaseMiceTransgenicPresenilin-1
Papaverine-Derived Dual-Active Modulator Ameliorates Alzheimer's Disease Pathology in Aged APP/PSEN1 Transgenic Mice.
Ashish Kumar, Madhu Ramesh, Jikesh Bhoi, Thimmaiah Govindaraju
Published: 202610.1021/acs.jmedchem.5c03360
Abstract
Alzheimer's disease (AD) therapeutics remain a challenge due to their complex pathology and multifactorial toxicity. Advanced stages of AD are marked by rapid cognitive decline, driven by amyloid plaques, neurofibrillary tangles, neuroinflammation, s…
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