Journal of medicinal chemistryPPAR gammaAnimalsArthritisGoutyNLR Family
Optimization of Ascidian-Derived Herdmanine D: Targeting Gouty Arthritis via the PPAR-γ/NF-κB/NLRP3 Pathway.
Xinlin Zhu, Yi Dong, Ya Zhang, Chenghai Gao, Lijian Ding, Yonghong Liu, Zhiran Ju
Published: 202610.1021/acs.jmedchem.5c03246
Abstract
Gouty arthritis, driven by monosodium urate (MSU) crystal deposition and dysregulated inflammation, remains a therapeutic challenge due to the limitations of current treatments. Here, we investigate Herdmanine D (HDD), a marine-derived alkaloid from…
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