Enhancing the Oral Bioavailability of a Poorly Soluble Pan-CK2 Kinase Inhibitor: Leveraging a Phosphate Prodrug Strategy to Overcome Dissolution-Limited Absorption and Improve Systemic Exposure during Dose Escalation.

Murugaiah A M Subbaiah, Naveen Manjunath, Thangeswaran Ramar, Mathiazhagan Annadurai, Naveen Kumar Dhondi, Tarun Sharma, Sheelendra Singh, Megha Thakur, Priyadeep Bhutani, Shahe Mahammad, Srinivas Kasibhatla, Sridhar Desikan, Kurt Zimmermann, Xiaopeng Sang, Gerry Everlof