Journal of medicinal chemistry
Synthesis and Translational Assessment of Trinucleotide 5'-Cap Analogs for Messenger Ribonucleic Acid-Based Therapeutics.
Jeeyeon Kim, Kyeongwon Moon, Jihun Kim, Sung-Jun Park, Nari Kim, Yonggyu Jung, Yoonsuk Lee, Kyoungmin Lee, Wokchul Yoo, Jong Hoon Kim, Byeong-Won Kim, Daseul Kim, Hyun-Ju Park, Jaeheon Lee, Pargat Singh
Published: 202610.1021/acs.jmedchem.5c03109
Abstract
Capping is a natural and distinctive modification that occurs at the 5'-end of eukaryotic messenger RNA (mRNA), which regulates biological functions for gene expression events. Recently, the synthetic variation of a 5'-cap element has attracted consi…
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