Journal of medicinal chemistry
PlatinumIV Complex Enabling Multiple and Potent Tumor Microenvironment Remodeling for Cancer Chemo-Immunotherapy.
Rensong Sun, Zhihao Chen, Ruitao Yang, Yuan Liang, Wen Sun, Engin U Akkaya, Lei Wang
Published: 202610.1021/acs.jmedchem.5c03032
Abstract
Tumor microenvironment not only compromises the therapeutic efficacy of chemotherapy but also weakens chemotherapy-induced immunogenic cell death. Herein, we report novel platinumIV prodrugs that integrate two clinically approved drugs with different…
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