Journal of medicinal chemistryAnimalsHumansFructokinasesEnzyme InhibitorsRats
The Discovery of GS-1291269: A Neutral Ketohexokinase (KHK) Inhibitor with an Unusual Thietane Amine Functional Group.
Zachary A Kasun, Xiaomin Liang, Ryan D Ferrao, Joshua A Kaplan, Christopher T Clark, Megan E Neubig, Daniel H Byun, Shawn S Badal, Natalie Sroda, Tina Mistry, Nathaniel H Stanley, Kirk L Stevens, James L Bachman, Jennifer R Lo, Jennifer Loyer-Drew
Published: 202610.1021/acs.jmedchem.5c02896
Abstract
Ketohexokinase (KHK) is the primary enzyme involved in fructose metabolism, converting fructose to fructose-1-phosphate (F1P). KHK is implicated in diseases, including metabolic-dysfunction-associated steatotic liver disease (MASLD) and diabetic kidn…
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