Journal of medicinal chemistryAnimalsHumansZirconiumNeuroblastomaMice
Development of [89Zr]Zr-DFO-hu3F8 and [225Ac]Ac-DOTA-hu3F8 Theranostic Pairs Targeting GD2 in Neuroblastomas.
Lingling Zheng, Xu Yang, Jun Liu, Guanyun Wang, Zi Ang Zhou, Yanfeng Xu, Jianhua Gong, Jigang Yang
Published: 202510.1021/acs.jmedchem.5c02837
Abstract
Relapsed and refractory high-risk neuroblastoma (NBL) patients have limited treatment options and a poor prognosis, highlighting the urgent need for novel targeted therapies. This study evaluates the GD2-targeting PET imaging agent [89Zr]Zr-DFO-hu3F8…
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