Journal of medicinal chemistryInterleukin-17TriazolesHumansStructure-Activity RelationshipGlutamine
Harnessing Glutamine-117 Plasticity toward Structure-Based Identification of Triazole IL-17 Inhibitors.
Matthias R Bauer, Juraj Velcicky, Alban Goetz, Pascal Furet, Pierre Nimsgern, Ritesh Tichkule, Achim Schlapbach, Arndt Meyer, Markus Vögtle, Catherine Rolando, Hansjoerg Lehmann, Frédéric Berst, Simone Riek, Patrick Schmutz, Sylvie Lehmann
Published: 202510.1021/acs.jmedchem.5c02794
Abstract
The proinflammatory cytokine IL-17 is crucial for host defense but has also been linked to various inflammatory and autoimmune diseases. Antibody-based IL-17 inhibitors like secukinumab (Cosentyx) have demonstrated clinical success in psoriasis, psor…
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