Journal of medicinal chemistryAnimalsPositron-Emission TomographyPyrazolesMiceFluorine Radioisotopes
Development and Preclinical Evaluation of Novel F-18-Labeled Dihydropyrazole RIPK1 PET Tracers for Neuroinflammation Imaging.
Hongyan Li, Zeyi Qin, Yanting Zhou, Hui Meng, Weiyao Xie, Pan Yao, Xinyu Yang, Huawei Cai, Lin Li, Changning Wang, Xiaoai Wu, Ping Bai
Published: 202510.1021/acs.jmedchem.5c02770
Abstract
Receptor-interacting protein kinase 1 (RIPK1) is a key mediator of inflammation and cell death, making it a promising target for diagnosing neurodegenerative diseases. In this study, we developed and evaluated two novel dihydropyrazole-based PET trac…
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