Journal of medicinal chemistryHelicobacter pyloriAnimalsDrug DesignAnti-Bacterial AgentsMice
Design, Synthesis, and Biological Evaluation of Acid-Responsive Bifunctional Molecules with Dual Anti-Helicobacter pylori and Acid Suppression Activities.
Rui Wen, Gang Xing, Hao Li, Jianuo Yang, Hanqing Xu, Ting Wang, Xingqi Hu, Canyao Ding, Huali Yang, Jiang Zheng, Rong Zhang, Mingyu Xia, Yang Liu, Maosheng Cheng
Published: 202610.1021/acs.jmedchem.5c02747
Abstract
The increasing antibiotic resistance of Helicobacter pylori necessitates novel therapeutics. Although rifabutin demonstrates potent anti-H. pylori activity and low resistance rates, its clinical use is limited by myelosuppressive risk. Clinical evide…
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