Journal of medicinal chemistry
Reversing the Hypoxic Adaptive Response in Breast Cancer Cells through Small-Molecule Inhibition of Oncogenic MicroRNA-210.
Marc Panosetti, Donatella Vecchio, Chloé Maucort, Vera Mongiardini, Audrey Di Giorgio, Benedetto Grimaldi, Maria Duca
Published: 202610.1021/acs.jmedchem.5c02728
Abstract
MicroRNA-210 (miR-210) is a key regulator of the hypoxic adaptive response in cancer cells, making it an attractive therapeutic target. In our continuous search for small-molecule inhibitors of oncogenic miRNAs, we designed a novel series of tris-thi…
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