Journal of medicinal chemistry
Systematic Optimization of Fragment TLX Ligands toward Agonism and Inverse Agonism.
Emily C Hank, Loris Knümann, Úrsula López-García, Arthur Kardanov, Vasily Morozov, Georg Höfner, Daniel Merk
Published: 202610.1021/acs.jmedchem.5c02718
Abstract
The transcription factor tailless homologue (TLX, NR2E1) maintains persistence of neural stem cells (NSCs) in a proliferating, undifferentiated state, thereby controlling NSC homeostasis and enabling neurogenesis. TLX is responsive to small-molecule…
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