Journal of medicinal chemistry
Peptidomimetics Inspired by α-Synuclein or Its Chaperone αB-Crystallin Differentially Modulate α-Synuclein Aggregation.
Nicolo Bisi, Josine Kothuis, Julia Kaffy, Helena Pérez Peña, Celina Schulz, Chiara Maria Giulia De Luca, Arianna Ciullini, Ilaria Linda Dellarole, Léa Radal, Fabio Moda, Graziella Cappelletti, Dragos Horvath, Stefano Pieraccini, Wolfgang Hoyer, Frédéric Halgand
Published: 202610.1021/acs.jmedchem.5c02716
Abstract
Aggregation of the α-Synuclein (αSyn) protein in neurons is responsible for synucleinopathies such as Parkinson's disease. In healthy cells, αSyn is primarily present as monomers. Under pathological conditions, oligomers and fibrils are formed, leadi…
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