Journal of medicinal chemistry
The Discovery of RGH-706, a Highly Efficacious MCH1 Receptor Antagonist, for the Treatment of Obesity and Insatiable Hunger.
Gyula Beke, András Boros, György M Keserű, Balázs Krámos, Krisztina Katalin Szalai, Anikó Gere, Mónika Vastag, Márta Thán, Balázs Varga, Ottilia Balázs, Sándor Farkas, Balázs Lendvai, István Greiner, János Éles
Published: 202610.1021/acs.jmedchem.5c02708
Abstract
The discovery and characterization of a novel 2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,7-a]indole derivative MCH1 receptor antagonist (37) is disclosed. Starting from our previously investigated pyrazino[1,2-a]indole series and utilizing a scaffold hop…
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