Journal of medicinal chemistryCamptothecinHumansAnimalsImmunoconjugatesMice
Discovery and Preclinical Evaluation of PBX-7016, a Methylenedioxy-Camptothecin Payload for Antibody-Drug Conjugates with Enhanced Therapeutic Potential.
Younghwa Chun, Byeong Sung Lee, Sohui Kweon, Hyemin Han, Seunggun Shin, Jaehyun Lee, Woogyum Kim, Jinhwan Cho, Byounggyu Yoo, Joonsun Yoon, Sungjae Yang, Doo Young Jung, Gangadhar Rao Mathi
Published: 202610.1021/acs.jmedchem.5c02706
Abstract
Camptothecin derivatives have become cornerstone payloads in antibody-drug conjugates (ADCs), with recent clinical success driving continued optimization to improve therapeutic efficacy and safety. Herein, we present the development of PBX-7016 (14),…
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