Journal of medicinal chemistry
Dual PARP/NAMPT Inhibitors for BRCA Wild-Type Triple-Negative Breast Cancer: Disrupting Homologous Recombination Repair and Activating Antitumor Immunity.
Kaizhen Wang, Dexiang Wang, Jun Tong, Zepeng Liao, Zhiyi Zhang, Qi Miao, Zhongyu Li, Yikun Liu, Jiating Li, Sheng Jiang, Tianyu Wang, Kuojun Zhang
Published: 202610.1021/acs.jmedchem.5c02659
Abstract
Simultaneously inhibiting PARP and NAMPT has demonstrated synergistic efficacy in BRCA wild-type TNBC through synthetic lethality, offering a promising strategy to broaden the clinical utility of PARP inhibitors. Here, we report the rational design a…
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