Journal of medicinal chemistryAntiviral AgentsPyrimidinesHumansAnimalsStructure-Activity Relationship
Discovery and Optimization of First-in-Class Furopyrimidine-Based Inhibitors of Henipaviruses.
Irina N Gaisina, Malaika D Argade, Ryan Bott, Sean P Bradley, Łukasz Tomorowicz, Mario Alvarez, Jazmin M Galván Achi, Robert W Cross, Viktoriya Borisevich, Rachel O'Toole, Moushimi Amaya, Christian A Zielinski, Arsen M Gaisin, Dejan Nikolic, Paul R Carlier
Published: 202610.1021/acs.jmedchem.5c02646
Abstract
Henipaviruses such as Nipah (NiV) and Hendra (HeV) are zoonotic pathogens that cause severe and often fatal respiratory illness and encephalitis in both animals and humans. These viruses exhibit high transmissibility and pandemic potential, a situati…
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