Journal of medicinal chemistryLeukocyte ElastaseBronchiectasisHumansAnimalsDrug Design
Design, Synthesis, and Biological Evaluation of the Novel Neutrophil Elastase Inhibitor CHF-6333 for the Inhaled Treatment of Bronchiectasis.
Elisabetta Armani, Andrea Rizzi, Daniela Miglietta, Irene Bassanetti, Francesco Amadei, Giandomenico Brogin, Carmelida Capaldi, Fabio Rancati, Chiara Carnini, Sergio Xanxo Fernandez, Maurizio Civelli, Paola Puccini, Marta Bellini, Andrew Jennings, Robert A Heald
Published: 202510.1021/acs.jmedchem.5c02638
Abstract
The inhibitors of neutrophil elastase (NE) have long attracted interest for the treatment of respiratory diseases. We report the breakthrough of a new potent, selective NE inhibitor with a 24 h duration of action: CHF-6333, is currently undergoing cl…
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