Journal of medicinal chemistry
Synergistic Effect of Phenylalanine Residues Governs the Mechanism of Membrane Disrupting Action of Aurein 1.2.
Zahra Nadia Saadatmand, Shiwen Zhu, Adam Mechler, Thorsten Wohland
Published: 202610.1021/acs.jmedchem.5c02612
Abstract
Aurein1.2 is a broad-spectrum antimicrobial peptide secreted by the Australian tree frog Litoria aurea. There are indications that the mechanism of action of aurein1.2 is driven primarily by the two phenylalanine (Phe) residues at the 3 and 13 positi…
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