Journal of medicinal chemistryHumansPyridinesPositron-Emission TomographyDrug DesignSerine Endopeptidases
Novel Pyridine-Based Fibroblast Activation Protein-Targeted Tracers: Design, Synthesis, and PET Imaging Evaluation for Tumors.
Ziyue Yu, Yong Huang, Zeng Jiang, Hualong Chen, Xuebo Cheng, Yajing Liu, Ying Liang, Zehui Wu
Published: 202510.1021/acs.jmedchem.5c02595
Abstract
To overcome the short tumor retention and nonspecific uptake of quinoline-based FAP inhibitors (e.g., FAP-46), we employed scaffold hopping to design novel phenylalanine-pyridyl-glycyl-prolamide derivatives. Among synthesized compounds (1a-i), multim…
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