Journal of medicinal chemistryReceptorsCalcitriolB7-H1 AntigenHumansLigands
Mechanism of Inhibition of the MeTC7 Ligand That Covalently Binds to VDR To Reduce PD-L1 Expression.
Jérôme Castel, Carole Peluso-Iltis, Angelique Sanchez Dafun, Aurora Silvestri, Judit Osz, Negar Khazan, Naohiro Yano, Kyu Kwang Kim, Rachael B Rowswell-Turner, Thierry Guiberteau, Yuki Teramoto, Hiroshi Miyamoto, Richard G Moore, Rakesh K Singh, Sarah Cianférani
Published: 202510.1021/acs.jmedchem.5c02589
Abstract
Cancer-associated overexpression of the Vitamin D Receptor (VDR) is associated with good or poor prognosis, depending on the cancer type and stage. Here, we show that VDR is overexpressed in ovarian malignant tissues and upregulates PD-L1 surface exp…
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