Journal of medicinal chemistryHumansColonDrug DesignSmall Molecule LibrariesModels
A Novel Colon PBPK Model: Navigating the Rational Drug Design for Small-Molecule Colon-Selective Therapies.
Rui Li, Dipy Vasa, Michael C Roy, Cheng Chang
Published: 202510.1021/acs.jmedchem.5c02469
Abstract
Developing small-molecule colon-selective therapies for localized drug action is an attractive strategy in treating colonic diseases. Due to the lack of a reliable approach to understand human colon exposures, there have been few successful examples…
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