Journal of medicinal chemistry
Design, Synthesis, and Biological Evaluation of Chromone Derivatives as STAT1 Inhibitors for Treatment of Nonalcoholic Steatohepatitis.
Zhipeng Zhang, Hongyan Lai, Shaofang Tian, Yingjie Song, Cunwuliji Na, Xiang Shi, Changhong He, Liuye Shi, Shengyun Wang, Fawad Ali, Fu Shu, Baoshun Zhang
Published: 202610.1021/acs.jmedchem.5c02431
Abstract
Nonalcoholic steatohepatitis (NASH) is a chronic liver disease with a high global incidence rate, intricately linked to metabolic disorders. It is characterized by steatosis, inflammation, and hepatocyte ballooning. STAT1 is a transcription factor in…
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