Journal of medicinal chemistry
Optimizing the Antibiotic Potency and Metabolic Stability of Pyridomycin Using a Semisynthetic Approach.
Katherine Valderrama, Oliver Horlacher, Gabriel Publicola, Patrick Eisenring, Maryline Kienle, Samira Boarbi, Mehdi Kiass, Jana Korduláková, Jonathan Chatagnon, Catherine Piveteau, Florence Leroux, Karin Savková, Monika Záhorszká, Francois-Xavier Cantrelle, Christian Lherbet
Published: 202610.1021/acs.jmedchem.5c02409
Abstract
Pyridomycin is a natural product with potent activity against Mycobacterium tuberculosis (Mtb), acting through direct inhibition of the fatty acid synthesis enzyme InhA. As a direct inhibitor, pyridomycin maintains activity on Mtb strains resistant t…
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