Journal of medicinal chemistryPositive Regulatory Domain I-Binding Factor 1HumansAnimalsLigandsMultiple Myeloma
Discovery and Characterization of Novel BLIMP-1 Heterobifunctional Ligand-Directed Degraders.
Bryan J Simmons, Lynda Groocock, Jesus Moreno, David S Peters, Meredith E Hughes, Vijay Veeravalli, Jennifer M Crawford, Matthew Chalkley, Mark Griffith, Melissa Plooster, Bo Hu, Jim Gamez, Jim Leisten, Michael J Barnes, Jason Chinn
Published: 202510.1021/acs.jmedchem.5c02363
Abstract
B-lymphocyte-induced maturation protein 1 (BLIMP-1/PRDM1) is a master transcriptional repressor essential for terminal differentiation of activated B-cells into bone-marrow resident plasma cells. Multiple myeloma (MM) is a plasma cell malignancy wher…
Preview only. Read the full abstract at the source