Journal of medicinal chemistry
Structure-Activity Relationships of Silver(I)- and Gold(I)-NHC Complexes Reveal Distinctly Different Responses of Cisplatin-Resistant Ovarian Cancer to Bis-NHC-Gold(I) Derivatives.
Julia H Bormio Nunes, Christina Hacker, Monika Caban, Daniel Valcanover, Patrick A Yassemipour, Sebastian Türck, Ingo Ott, Lukas Skos, Andrea Bileck, Christopher Gerner, Samuel M Meier-Menches, Thomas Mohr, Walter Berger, Christian R Kowol, Petra Heffeter
Published: 202610.1021/acs.jmedchem.5c02355
Abstract
Ovarian cancer (OC) is the most lethal gynecological malignancy, with platinum resistance posing a major therapeutic challenge. To explore alternatives, we synthesized silver- and gold-based N-heterocyclic carbene (NHC) complexes differing only in th…
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